{"id":18915,"date":"2022-01-07T18:39:28","date_gmt":"2022-01-07T17:39:28","guid":{"rendered":"https:\/\/ilts.org\/?post_type=news&#038;p=18915"},"modified":"2022-01-07T18:46:47","modified_gmt":"2022-01-07T17:46:47","slug":"covid19-vaccine-effectiveness-transplant-recipients","status":"publish","type":"news","link":"https:\/\/old.ilts.org\/news\/covid19-vaccine-effectiveness-transplant-recipients\/","title":{"rendered":"NEW PUBLICATION: Real-world Effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S Vaccines Against SARS-CoV-2 in Solid Organ and Islet Transplant Recipients"},"content":{"rendered":"<p><em>Chris J. Callaghan; Lisa Mumford; Rebecca M.K. Curtis; Sarah V. Williams; Heather Whitaker; Nick Andrews; Jamie Lopez Bernal; Ines Ushiro-Lumb; Gavin J. Pettigrew; Douglas Thorburn; R. Forsythe; Romme Ravanan on behalf of the NHSBT Organ and Tissue Donation and Transplantation Clinical Team<\/em><\/p>\n<p>&nbsp;<\/p>\n<p>On August 31, 2021, it was found that 3080 (7.1%) were unvaccinated, 1141 (2.6%) had 1 vaccine dose, and 39\u2009260 (90.3%) had 2 vaccine doses. There were 4147 SARS-CoV-2 infections and 407 deaths (unadjusted case fatality rate 9.8%). The risk-adjusted infection incidence rate ratio was 1.29 (1.03-1.61), implying that vaccination was not associated with reduction in risk of testing positive for SARS-CoV-2 RNA. Overall, the hazard ratio for death within 28 d of SARS-CoV-2 infection was 0.80 (0.63-1.00), a 20% reduction in risk of death in vaccinated patients (<em>P<\/em>\u2009=\u20090.05). Two doses of ChAdOx1-S were associated with a significantly reduced risk of death (hazard ratio, 0.69; 0.52-0.92), whereas vaccination with BNT162b2 was not (0.97; 0.71-1.31).<\/p>\n<p>&nbsp;<\/p>\n<h3>Read the full publication <a href=\"https:\/\/journals.lww.com\/transplantjournal\/Abstract\/9000\/Real_world_Effectiveness_of_the_Pfizer_BioNTech.95099.aspx\">here<\/a>:<\/h3>\n<p><a href=\"https:\/\/journals.lww.com\/transplantjournal\/Abstract\/9000\/Real_world_Effectiveness_of_the_Pfizer_BioNTech.95099.aspx\">https:\/\/journals.lww.com\/transplantjournal\/Abstract\/9000\/Real_world_Effectiveness_of_the_Pfizer_BioNTech.95099.aspx<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Transplantation: <a href=\"https:\/\/journals.lww.com\/transplantjournal\/toc\/9000\/00000\">January 04, 2022 &#8211; Volume &#8211; Issue &#8211; <\/a> doi: 10.1097\/TP.0000000000004059<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The clinical effectiveness of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in immunosuppressed solid organ and islet transplant (SOT) recipients is unclear.<\/p>\n","protected":false},"featured_media":18917,"template":"","acf":[],"_links":{"self":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/news\/18915"}],"collection":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/news"}],"about":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/media\/18917"}],"wp:attachment":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/media?parent=18915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}