{"id":22428,"date":"2023-07-17T11:39:08","date_gmt":"2023-07-17T09:39:08","guid":{"rendered":"https:\/\/ilts.org\/?post_type=news&p=22428"},"modified":"2023-07-17T12:17:49","modified_gmt":"2023-07-17T10:17:49","slug":"what-were-reading-july-2023","status":"publish","type":"news","link":"https:\/\/old.ilts.org\/news\/what-were-reading-july-2023\/","title":{"rendered":"What We\u00b4re Reading\u2026 July 2023"},"content":{"rendered":"\n

The July issue of Transplantation<\/a>,<\/em> the official Journal of ILTS and the Transplantation Society, is out now.
A must-read for anyone working in the field of liver transplantation.<\/strong><\/p>\n\n\n\n

Free access for ILTS members!<\/a><\/strong><\/p>\n\n\n\n

Article selections by Sadhana Shankar, Alessandra Mazzola, Beth Wilson, Jiang Liu, Carmen Vinaixa and Abdul Hakeem.<\/strong><\/p>\n\n\n\n

HEPATOLOGY<\/strong><\/p>\n\n\n\n

Hepatology<\/em>
A multi-society Delphi consensus statement on new fatty liver disease nomenclature<\/strong>
The principal limitations of the terms nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favour of a change in nomenclature and\/or definition. More<\/a><\/p>\n\n\n\n

Liver Transplantation\u00a0<\/em>
Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortiumorld<\/strong>
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT HCC recurrence risk remains an important need. Clinico-radiologic and pathologic data of 4981 patients with HCC undergoing LT from the US Multicenter HCC Transplant Consortium (UMHTC) were analyzed to develop a REcurrent Liver cAncer Prediction ScorE (RELAPSE). Multivariable Fine and Gray competing risk analysis and machine learning algorithms (Random Survival Forest and Classification and Regression Tree models) identified variables to model HCC recurrence. RELAPSE was externally validated in 1160 HCC LT recipients from the European Hepatocellular Cancer Liver Transplant study group. More<\/a><\/p>\n\n\n\n

Journal of Hepatology
<\/em>Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation<\/strong><\/strong>
Background and aims:\u00a0<\/strong>We previously demonstrated that people with primary sclerosing cholangitis (PSC) had reduced gut microbial capacity to produce active vitamin B6 (pyridoxal 5′-phosphate [PLP]), which corresponded to lower circulating PLP levels and poor outcomes. Here, we define the extent and biochemical and clinical impact of vitamin B6 deficiency in people with PSC from several centers before and after liver transplantation (LT). More<\/a><\/p>\n\n\n\n

<\/p>\n\n\n\n

SURGERY<\/strong><\/p>\n\n\n\n

Journal of Hepatology<\/em>
Machine perfusion techniques for liver transplantation – A meta-analysis of the first<\/strong> seven randomized controlled trials<\/strong>
Background & aims:\u00a0<\/strong>Machine perfusion is increasingly tested in clinical transplantation. Despite this success, the number of large prospective clinical trials remains limited. The aim of this study is therefore to compare the impact of machine perfusion on outcomes after liver transplantation versus static cold storage (SCS). <\/a>More<\/a><\/p>\n\n\n\n

Annals of Surgery<\/em>
The Evolution of Redo Liver Transplantation Over 35 years: Analysis of 654 Consecutive Adult Liver Retransplants at a Single Center<\/strong>
Objective:\u00a0Despite the durability of liver transplantation (LT), graft failure affects up to 40% of LT recipients. We examined liver retransplantation (ReLT) over 35-years at a single center. Methods:\u00a0All adult, ReLTs from 1984-2021 were analyzed. Comparisons were made between ReLTs in the pre- vs. post- model for end-stage liver disease (MELD) eras and between ReLTs and primary-LTs in the modern era. Multivariate analysis was used for prognostic modeling. More<\/a><\/p>\n\n\n\n

Sex-based Disparities in Access to Liver Transplantation for Waitlisted Patients With Model for end-stage Liver Disease Score of 40<\/strong>
Objective:\u00a0To determine the association of sex with access to liver transplant among candidates with the highest possible model for end-stage liver disease score (MELD 40). Background:\u00a0Women with end-stage liver disease are less likely than men to receive a liver transplant, due in part to MELD’s underestimation of renal dysfunction in women. The extent of the sex-based disparity among patients with high disease severity and equally high MELD scores is unclear. More<\/a><\/p>\n\n\n\n

ANESTHESIOLOGY AND CRITICAL CARE<\/strong><\/p>\n\n\n\n

Clinical Transplantation<\/em>
Intraoperative hypotension and the risk of acute kidney injury following liver transplantation <\/strong>
Background:\u00a0Acute kidney injury (AKI) is a frequent adverse outcome following liver transplantation (LT) with a multifactorial etiology. It is critical to identify modifiable risk factors to mitigate the risk. One key area of interest is the role of intraoperative hypotension, which remains relatively unexplored in liver transplant cohorts. More<\/a><\/p>\n\n\n\n

Korean Journal of Anesthesiology<\/em>
Postoperative alterations in ventriculo-arterial coupling is an indicator of cardiovascular outcomes in liver transplant recipients
<\/strong>Background: Liver transplantation (LT) surgery increase the workload on the heart and vessels in patients with cirrhotic cardiomyopathy. While the interaction of the left ventricle (LV) with the arterial system (ventricular-arterial coupling, VAC) is a key determinant of cardiovascular performance, little has been known about the changes in VAC after LT. Therefore, we evaluated the relationship between the VAC after LT and cardiovascular outcomes. More<\/a><\/p>\n\n\n\n

Liver Transplantation<\/em>
A randomized, controlled, prehabilitation intervention to maximize early recovery (PRIMER) in liver transplantation
<\/strong>Background and aims:\u00a0Frailty and impaired functional status are associated with adverse outcomes on the liver transplant (LT) waitlist and after transplantation. Prehabilitation prior to LT has rarely been tested. We conducted a two-arm patient randomized pilot trial to evaluate the feasibility and efficacy of a 14-week behavioral intervention to promote physical activity prior to LT. More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The July issue of Transplantation, the official Journal of ILTS and the Transplantation Society, is out now.A must-read for anyone working in the field of liver transplantation. Free access for ILTS members! Article selections by Sadhana Shankar,..<\/p>\n","protected":false},"featured_media":17241,"template":"","acf":[],"_links":{"self":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/news\/22428"}],"collection":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/news"}],"about":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/media\/17241"}],"wp:attachment":[{"href":"https:\/\/old.ilts.org\/api\/wp\/v2\/media?parent=22428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}